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Mar. 12, 2013 ? Mouse model studies show that administered genetically or topically, protein Smad7 protects against or heals mouth sores commonly associated with cancer treatment.
In some cancer patients treated with radiation, the mouth sores known as oral mucositis become so severe that feeding tubes are required for nutrition and narcotics are needed for pain. In fact, 40-70 percent of patients treated with upper-body radiation develop the condition to some degree. Currently, there is no FDA approved treatment. A University of Colorado Cancer Center study published this week in the journal Nature Medicine takes an important step toward changing that.
"We developed a genetically engineered mouse that produces a protein called Smad7 in the surface layers of its mouth. With this protein expressed, mouse models were dramatically more resistant to the development of oral mucositis than were controls," says Xiao-Jing Wang, PhD, CU Cancer Center investigator and John S. Gates endowed Chair of Cancer Stem Cell Biology at the Charles C. Gates Center for Regenerative Medicine and Stem Cell Biology.
Wang and collaborators including Qinghong Zhang, PhD, Yosef Refaeli, PhD, and radiation oncologist David Raben, MD, are pursuing further research with the goal of developing Smad7 as a therapeutic agent for human oral mucositis. For example, the group joined Smad7 in with a short peptide that allows the protein to cross through cell membranes, and produced this combination protein from cultured bacteria. When they applied the engineered compound directly to the mouse oral cavity, it both protected against the development of oral mucositis and worked to heal existing ulcers. Importantly, it revived wounded normal cells but not cancer cells, avoiding a major problem of growth factors currently used to promote the cell growth that heals ulcers.
"It's very reasonable to hope that this line of research will result in a drug that patients can self-administer topically to oral mucositis sores, or use to prevent them altogether, thus significantly improving the quality of life for many cancer patients," Wang ways.
Additionally, Wang points out that the mouse model engineered to develop human-like oral mucositis in the presence of radiation treatment is a useful tool for studying the disease -- offering opportunities to search for biomarkers and test experimental therapies.
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The above story is reprinted from materials provided by University of Colorado Denver. The original article was written by Garth Sundem.
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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/MeEGV8pSDVo/130312152051.htm
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Gonzaga's Elias Harris, of Germany, shoots during the second half of a West Coast Conference tournament NCAA college basketball game against Loyola Marymount, Saturday, March 9, 2013, in Las Vegas. Gonzaga defeated Loyola Marymount 66-48. (AP Photo/Isaac Brekken)
Gonzaga's Elias Harris, of Germany, shoots during the second half of a West Coast Conference tournament NCAA college basketball game against Loyola Marymount, Saturday, March 9, 2013, in Las Vegas. Gonzaga defeated Loyola Marymount 66-48. (AP Photo/Isaac Brekken)
Gonzaga's Drew Barham passes as Loyola Marymount's Nick Stover defends during the first half of a West Coast Conference tournament NCAA college basketball game on Saturday, March 9, 2013, in Las Vegas. (AP Photo/Isaac Brekken)
Loyola Marymount's Alex Osborne and Gonzaga's Mike Hart reach for a rebound during the first half of a West Coast Conference tournament NCAA college basketball game Saturday, March 9, 2013, in Las Vegas. (AP Photo/Isaac Brekken)
Gonzaga's Kevin Pangos, of Canada, center, shoots while covered by Loyola Marymount's Nick Stover, left, and Alex Osborne, right, during the second half of a West Coast Conference tournament NCAA college basketball game on Saturday, March 9, 2013, in Las Vegas. Gonzaga defeated Loyola Marymount 66-48. (AP Photo/Isaac Brekken)
Gonzaga's Kevin Pangos (4), of Canada, defends against Loyola Marymount during the second half of a West Coast Conference tournament NCAA college basketball game on Saturday, March 9, 2013, in Las Vegas. Gonzaga switched to a zone defense during the second half and defeated Loyola Marymount 66-48. (AP Photo/Isaac Brekken)
LAS VEGAS (AP) ? For the first time in school history, Gonzaga stepped on the floor as the top-ranked team in the country.
Thanks to a second-half surge Saturday night in the semifinals of the West Coast conference tournament, it'll step on the floor Monday night in the championship game of the event as the nation's No. 1 team for a second straight week.
Elias Harris had 21 points and eight rebounds to lead Gonzaga over Loyola Marymount 66-48.
Bidding for a top seed in the NCAA tournament, the Bulldogs (30-2) advanced to play for the league championship against the winner of Saturday's late semifinal between Saint Mary's and San Diego.
Challenged in the first half by a team that went 1-15 in WCC play this season, Gonzaga turned up the defensive intensity and opened the second half on a 19-5 run to seize momentum.
Though it needed a last-second basket by Sam Dower to take a 27-26 lead into halftime, Gonzaga outscored the Lions 39-22 in the second half.
Kevin Pangos added 14 points and Kelly Olynyk had eight points and eight rebounds for the Zags.
Anthony Ireland led Loyola Marymount (11-23) with 19 points.
"LMU is a bunch of fighters," Gonzaga coach Mark Few said. "They are tough and reflect the personality of their coach. I thought we played excellent defense all night, especially in the second half. We finally got our offense going in the second half."
After shooting 40 percent (8 of 20) from the field in the first half, including 4 of 10 from beyond the arc, the Lions shot a dismal 7 of 29 (24.1 percent) from the field in the second. LMU was an abysmal 1 of 10 from 3-point range.
Conversely, the Zags turned it around after a horrendous first half ? during which they went 9 of 24 from the field and 1 of 7 on 3s ? and was a blistering 11 of 22 from the floor, including 4 of 7 from long range.
"We played with more emotion in the second half," Harris said. "We came out flat in the beginning and knew we that we had to change that."
The Lions forced 45 turnovers ? and committed only 32 ? in their first three games of the tournament, but last night came up against a Gonzaga team much more disciplined than their previous foes, and bit more tenacious on defense. And while LMU committed 16 miscues, compared to Gonzaga's 13, the Bulldogs outscored the Lions 19-6 off turnovers.
Gonzaga also outrebounded the Lions 38-31, while outscoring them in the paint 28-12.
"I have tremendous respect for coach Few and the Gonzaga team," Loyola coach Max Good said. "They are very talented. They are well coached and play with a lot of class. Our lack of size hurt us against a team with the big men of Gonzaga. We had to hustle and scrap, which we did, but in the end it just wasn't enough."
Much of the Zags' domination came in the second half, though, as LMU refused to go away over the first 20 minutes. The Lions held Gonzaga scoreless early on, for a little more than three minutes, while going on a 9-0 run to take a 14-9 lead. The Bulldogs returned the favor by going on a 7-0 run, while holding Loyola scoreless for a bit less than three minutes, to take a 16-14 lead.
From there the two continued to play back and forth while neither built a margin bigger than two points, with the lead changing hands seven times over the final 4:16 of the half.
The ninth-seeded Lions, who posted one win in the first two months of the calendar year, tripled that figure in the WCC tournament with three straight wins to get to the semifinals.
LMU knocked off No. 8 Portland 65-54 on Wednesday to wedge its way into the bracket. The Lions upset No. 5 San Francisco 61-60 in overtime on Thursday then stunned fourth-seeded Santa Clara 60-58 on Friday.
Harris said the WCC tournament was "great preparation" for the NCAA championship games, saying "it's getting us well-prepared for the more competitive challenge."
The Bulldogs, who earned the WCC's top seed for the 13th time, were the first team to go 16-0 in the league in the two years of the 16-game format. It was their fourth undefeated West Coast campaign, also going unbeaten in 2004, 2006 and 2009, when the conference played a 14-game schedule, prior to BYU joining the conference.
"Over this great run with great players (a No. 1 national ranking and a 30-win season) are things that we have not been able to accomplish," Few said. "They are both special because it is a culmination of an entire year of work, not just a week or two of being hot."
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Rashad Evans, the one-time UFC light heavyweight champion, made his position on same-sex marriage clear. He's for it, because equality in the world makes it better for everyone.
When asked by Outsports of his thoughts on the issue, Evans issued this incredibly smart, well-thought-out response. His statement in full:
?I've never been a homophobe, never understood what that is all about. I knew some people who were gay and never cared about their sexuality. But at the same time, I didn't fully understand the issues around gay people until my friend BA started telling me about his full public support for gay marriage. We talked about the issue and I decided its not enough to not be against a minority, if you want things to go better for them you have to speak up with them.
?I'm a UFC fighter, a macho-type sport. I am a heterosexual guy in a tough macho sport, which is exactly the reason I feel a duty to say I support gay marriage and gay rights.
?I have nothing to gain personally from supporting this issue, and that's the point. Society as a whole is better when there is equality, and I want to live in a country where everyone has the same rights because we all benefit from that.
?What people overlook is that is isn't a sex issue, its a love issue. There's no justifiable reason for trying to get in the way of two people who love each other.
?I have kids. I don't want them growing up in a society where they, or their friends, could be second class citizens based on which person they fall in love with or who they want to be happy with.?
As he pointed out, the MMA world can be a macho place where instances of homphobia are overlooked. The sport has improved, as Liz Carmouche became the first gay fighter in the UFC when she fought Ronda Rousey at UFC 157. The same weekend Carmouche fought, UFC president Dana White said he would welcome a gay male fighter, and would deal with any fighter who would have a problem with it.
But well-known former champion standing up for marriage equality shows that the MMA world is one that can be welcoming and supportive.
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LONG BEACH, N.Y.?? It sounds like the premise for a new reality TV series: "Hurricane House" ? people scouring waterside communities looking to buy homes damaged by Superstorm Sandy at a deep discount.
While there are bargains out there, ranging from 10 percent off pre-storm prices for upscale homes on New York's Long Island and the Jersey Shore to as much as 60 percent off modest bungalows Staten Island and Queens, it's still very much a game of buyer beware.
Not only are buyers are on the hook for repairs and in some cases total rebuilds, they're also wading into a host of potentially expensive uncertainties about new flood maps and future insurance rates, zoning changes and updated building codes.
"It's totally changed the way I sell real estate," said Lawrence Greenberg, a sales associate with Van Skiver Realtors, whose own Mantoloking, N.J., office was wrecked in the storm.
Prior to Sandy, prospective buyers rarely mentioned issues such as flood maps and building elevations until the matter of flood insurance came up ? often at closing. "Now, everybody asks the question of elevation," Greenberg said. Even if potential buyers plan to tear down and build new, they ask about the pending changes in flood maps proposed by the Federal Emergency Management Agency, because flood insurance rates will depend upon the new zones.
There is no sign of a mass exodus from shoreline communities. The number of for-sale listings in January in the 380 zip codes hit by the storm was about 2 percent below the same time last year, according to online real estate information company Zillow Inc. That indicates that most homeowners are rebuilding, or have not yet decided how to proceed.
But real estate agents in New York and New Jersey say the majority of homes for sale in these areas have some damage from the Oct. 29 storm, and it appears to them that a rising number are being put on the market as the spring home-buying season approaches.
New listings range from destroyed oceanfront properties being sold for the land, to flooded bayside homes untouched since the storm that must be gutted. Even the few undamaged homes in affected neighborhoods are listing at prices about 10 percent lower than they would have been pre-storm.
Some sellers are overwhelmed by the daunting prospect of restoring a damaged home. Some are older homeowners who had stayed in the houses where they raised their families, but now are relocating. Some didn't have flood insurance.
"They either don't have the funds or don't have the energy to go through the renovating and rebuilding process," said Jeff Childers, a broker with Childers Sotheby's International Realty in Normandy Beach, N.J.
Lisa Jackson, broker and owner of Rockaway Properties in the Belle Harbor section of Queens, N.Y., said a number of her new listings are homes owned by senior citizens. One 85-year-old client was living alone in her 1940s-era six-bedroom, six-bath brick home right on the beach. The house was hammered by Sandy, and must be at least partially demolished, but will still command a hefty price. "Everything on the water is big money," Jackson said.
But the $3 million listing price is nevertheless a huge discount from the roughly $4.25 million it would have commanded before the storm.
Another set of sellers were in the process of getting out before the storm hit. Jackson had 18 properties in contract prior to Sandy, but all of those sales either fell through or were renegotiated for a lower price.
One 1930s-era three-bedroom, two-bath house with a view of the bay was in contract for $665,000, but the entire first floor was gutted after it took on about four feet of water. The buyer, a single woman, was unwilling to take on the renovations. The property is back on the market for $550,000. That's a 17 percent discount, but the eventual buyer will have to pay for new floors and walls, plus a new kitchen and bathroom.
Still, that sort of cut might make the neighborhood affordable for a family that was priced out in recent years, when houses were selling for $750,000 and more.
And in one sense, buying a storm-damaged home can offer an advantage, said Tom Tripodi, president of the Tripodi Group/ Douglas Elliman Real Estate in the Long Island city of Long Beach, where damaged houses are selling for about 10 percent less than before the storm.
"If it's all gutted out, you can do what you want," he said. "You can own the house with a brand new kitchen, new appliances, new floors."
In addition to people looking to create their dream house out of a damaged home, Tripodi has seen investors eyeing the area. In Long Beach's West End neighborhood, for example, investors are looking to tear down gutted 1920s-era ranch homes and build bigger houses with multiple stories at higher elevations in their place.
The shorefront sections of Staten Island are also seeing accelerating turnover of homes that are likely to eventually get torn down.
Lee Venezia, a broker with Neuhaus Realty Inc., recently sold three adjacent bungalows owned by a longtime resident of Staten Island's Midland Beach for $240,000 cash ? about $20,000 less than each one might have garnered before the storm. "The homeowner refused to go back," she said.
The buyer will fix the properties up and rent them "until the dust settles," Venezia said. Once new flood maps are finalized and new building codes sorted out, she expects the houses to be sold again to a developer who will replace them.
Cash deals are the only ones closing right now in Staten Island's storm-damaged neighborhoods, Venezia said, which means the buyers are almost all investors, even though the area's small houses are selling for $85,000 to $100,000. "Banks are not going to lend," she said. "The banks are waiting for the dust to settle to see what the building requirements are going to be."
The new flood maps must go through public hearings before they are finalized, a process likely to take two to three years.
Meanwhile, public officials and homeowners are trying to look to the future.
New York Gov. Andrew Cuomo recently announced a plan to buy out the entire Staten Island neighborhood of Oakwood Beach and allow the land to revert back to the marshland it once was, because the homes there have flooded multiple times. It remains unclear if any other neighborhoods might get bought out.
That may be the best hope for homeowners like Michael Kuhens, who has been trying to sell his bungalow in Staten Island's Ocean Breeze section, which was ripped off its foundation by the 14-foot storm surge.
A buyout would be attractive because, instead of dealing with bargain hunters, the state is offering pre-storm value.
"I know a lot of people in my neighborhood don't want to stay, and if they were offered a buyout they'd take it," said Kuhens, who is staying at his parents' house with his wife and 1-year-old daughter. "We just want to get on with our lives. It's a hundred-something days after the storm, and we're still stuck in limbo."
Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Source: http://www.nbcnews.com/id/51124191/ns/weather/
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The annual CoStar Power Broker Awards have been announced and the winners include several top firms and real estate brokers in Denver. Recognizing the ?best of the best? in commercial real estate brokerage, the CoStar Power Broker Awards are presented each year to local real estate firms and individual brokers who achieved the highest transaction volume in commercial property sales and leases in their market during 2012.
The following top commercial real estate firms in Denver have been awarded CoStar Power Broker Awards for their exceptional deal-making accomplishments last year:
The winners range from national powerhouse firms to small boutiques, and recognize the outstanding deal-making achievements in 2012 by the top brokers and firms in over 90 markets across the U.S. The complete list of CoStar Power Broker awards winners listed alphabetically by market, including individual brokers, can be found here.
All CoStar Power Broker Awards are based on transaction data in CoStar?s commercial real estate database, believed to be the largest, independently researched source of commercial real estate property information in a unified database ever produced. Each year, CoStar tabulates the commercial real estate sales and lease transactions that closed during the previous year and presents CoStar Power Broker Awards to the brokerage firms and individual brokers who closed the highest transaction volumes in commercial property sales and leases in each market.
?CoStar is proud to honor the firms and brokers who perform at the industry?s highest level each year,? said CoStar Group Founder and CEO Andrew C. Florance. ?These industry leaders deserve to be recognized for their hard work, expertise and superior deal-making abilities. We extend our congratulations to this year?s winners on their achievements.?
Article source: http://www.costar.com/News/Article/Denver-Real-Estate-Brokers-Win-CoStar-Power-Broker-Awards/146479
Loren is a long-time Denver real estate investor. He has bought, remodeled and sold homes throughout the Denver metro area. Loren has also invested in commercial real estate. He is an entrepreneur who has owned multiple businesses and is a licensed real estate agent in the state of Colorado. Loren and his wife, Karen Bimler, make up Team Bimler at Your Castle Real Estate. If you would like more information about the Denver Real Estate market, give Loren a call at 720-837-0831. This entry was posted in Denver Real Estate News and tagged Andrew C, Awards Winners, Brokerage Firms, Commercial Real Estate, Denver Real Estate, Group Founder, Industry Leaders, Lease Transactions, Local Real Estate, National Powerhouse, Power Broker, Real Estate Brokers, Real Estate Sales, Sales And Leases, Top Brokers, Transaction Data, Transaction Volume, Transaction Volumes, Unified Database, Work Expertise. Bookmark the permalink.Source: http://denverrealestateblogger.com/1948/denver-real-estate-brokers-win-costar-power-broker-awards/
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12:10am
Don?t forget to Spring Forward before you go to bed. Severe threat has passed but careful driving out there, some flooding possible in Dallas, Collin and Grayson counties. Thank you for joining us on the blog today/tonight, seven hours of continuing coverage. See you tomorrow after basketball at 5:30pm.
11:45pm
Urban and Small Stream Flood Advisory for western Dallas County until 1:15am.?
Almost 1? rainfall in last 30 minutes just west of downtown Dallas. Street flooding, flooding in low-level areas and road construction sites expected. Please drive with caution.
11:33pm
Urban and Small Stream Flood Advisory for Collin and Grayson County until 3:30am.?
11:24pm
Heavy rain moving across Navarro County. No warnings out but lightning, gusty winds and heavy rain.
11:20pm
Heavy rain is the threat now for metro. Watch the roads around all those construction sites.
11:17pm
Heavy rain all over Dallas County. No lighting. Strong storms moving across Navarro County. No warnings but area is under a T?Storm Watch. Extended Forecast shows great weather in the week ahead. Near freezing (probably for the last time this season) Monday and Tuesday morning:
11:01pm
Thunderstorm Watch for north Texas expires save for our southern counties: a T?Storm Watch continues for Freestone, Limestone, Navarro and Hill counties until 3am.
10:52pm
Can easily make out small rotation in non-severe cell moving into Cedar Hill. Going to shake all the TV towers on the hill! Gusts near 50mph along with penny-size hail possible.
10:45pm
Non-severe cell over Garland moving toward Wylie and Lake Levon. Possible small hail with this one.
10:24pm
Severe weather threat confined to our southern counties over the next several hours; from Hill and Navarro counties to the east. Metro area will get some heavy rains. Half-dollar size hail over University Park reported earlier around 10pm.
10:05pm
No warnings out for the metro area (not one all night!) but a strong cell north of Dallas lifting NE at 30mph. Join us now at CBS11 for the latest on the storms and what we expect for the rest of the night
9:36pm
Cell over Grand Prairie showing rotation, headed toward downtown Dallas moving east along and north of I-30. Might go severe.
9:18pm
Weather Statement out on storm over Arlington, half-inch size hail, 40mph gusts along with heavy rain and lightning. Moving over Hwy 360 right now.
9:10pm
Small hail possible with storm cell moving over Arlington along with some frequent lighting and heavy rain. Watching closely. Severe storm over southern Bosque Co. still has some punch but losing some of its rotation.
9:00pm
Small hail possible over Arlington as storms continue to move east toward Dallas County.
Just so you know, our policy is NOT to cut-in if the weather is NOT SEVERE. We don?t like to get on air and warn people of storms that carry no warning. Storm season is long ?and dangerous enough across DFW area without us being alarmist about it.
8:45pm
Strongest cell of the event so far looks to be over southern tip of Bosque County. T?Storm Warning in place but showing rotation. Just out of reach of KTVT Doppler radar.
They have dropped the T?Storm Watch for Hood, Parker and Somervell counties.
8:40pm
Cell dropped some penny-sized hail over Lake Dallas is moving toward Celina and McKinney in Collin Co.
8:08pm
Line of heavy rain, small hail and frequent lightning in downtown Ft. Worth?and Cleburne over the next hour.
7:56pm
No Warnings out except south of our area. Line of strong storms will hit downtown Fort Worth and Cleburne within the next hour:
7:07pm
1? hail reported with storm cell moving into Azel and Eagle Mt. Lake area (NW corner of Tarrant County).
6:54pm
T-Storm Watch dropped for western counties. Metro area still included, runs until 11pm. Here is a map of the updated T-Storm Watch areas.
6:46pm
The circled area south of the metro area is where the risk of severe weather continues tonight.
6:44pm
Heavy Rain, small hail and frequent lightning the threat for Tarrant County when this line arrives over the next hour.
6:25pm
SEVERE THUNDERSTORM WARNING for Cooke, Denton, and Grayson County until 7:30pm
6:18pm
Severe Thunderstorm Warning CANCELLED for Parker County, Palo Pinto County, Hood County and Erath County. Airport Weather Warning reports lightning within 10 miles.
5:50pm
National Weather Service Fort Worth/Dallas reports line of storms has shown a downward trend in intensity.
5:28pm
National Weather Service Fort Worth/Dallas reports hail west of DFW. No reports of damaging winds yet.
5:23pm
SEVERE THUNDERSTORM WARNING for Erath County, Hood County, Palo Pinto County and Parker County until 6:15 pm. SEVERE THUNDERSTORM WARNINGS remains in effect for Comanche County and Eastland County until 6 pm.
5:16pm
SEVERE THUNDERSTORM WARNING for Southern Wise County. Storm moving NE at 45 mph . Capable of producing ping pong ball size hail and 60 mph winds.
5:12pm
Thunderstorm Warnings on this line stretch 181 miles from Brownwood to Cooke County. Large hail primary threat.
5:06pm
SEVERE THUNDERSTORM WARNING for Northern Comanche County and Eastland County until 6 pm. Storm moving northeast at 25 mph, capable of producing quarter size hail and 60 mph damaging winds.
4:53pm
Severe Thunderstorm Warning CANCELLED for southeastern Jack County.
4:53pm
Between 2.75 and 3.00 inch hail reported in Decatur.
4:53pm
Two inch diameter hail reported four miles north of Decatur.
4:51pm
Reports of one inch hail two miles north of Muenster.
4:40pm
SEVERE THUNDERSTORM WARNING remains in effect for Northwestern Wise County until 5:15 pm. Storm located near Chico moving NE at 45 mph, quarter size hail possible.
4:38pm
SEVERE THUNDERSTORM WARNINGS for Southeastern Jack County, Palo Pinto County and Western Parker County until 5:30 pm. Golf ball size hail and 60 mph winds possible. Will stay W and NW of metro until this evening.
4:33pm
SEVERE THUNDERSTORM WARNING for Wise County until 5:15 pm. Ping pong ball size hail possible and winds up to 60 mph. Severe T-Storms will be near Alvord and Decatur around 4:40 pm.
4:27pm
This cell really wrapping around on the rear flank. Large hail possible north end of Lake Bridgeport to Alvord.
4:21pm
Weather Advisory for Comanche County, Eastland County, Erath County and Palo Pinto County. Strong T-Storms 20 miles west of Mineral Wells moving northeast at 35 mph.
4:18pm
Thunderstorm Warning on this cell moving NE at 50 mph into St. Joe, large hail in cell.
4:15pm
SEVERE?THUNDERSTORM?WARNING for Southwestern Montague County until 5 pm. SEVERE THUNDERSTORM WARNING remains in effect for Northwestern Wise and Jack Counties until 4:30 pm.
4:10pm
Ping pong size hail or larger possible with this cell in Wise County. Same for cell in eastern Montague County.
4:03pm
Bowie reports 1.50 inch hail.
4:00pm
Line of severe weather will stay W, NW of DFW until this evening. Tornado threat higher along Red River over next three hours.
3:58pm
SEVERE THUNDERSTORM WARNING for Cooke County and Eastern Montague County until 5 pm. Severe T-Storm capable of ping pong ball size hail located seven miles northwest of Forestburg moving NE at 40 mph.
3:49pm
Weather Advisory for Southern Jack County and Palo Pinto County. Cell moving NE at 45 mph.
3:45pm
Hail in Bowie now one inch.?Severe cell producing hail, moving NE-50mph across central Montague County.
3:39pm
Bowie reports penny sized hail.
3:39pm
Jack County and Northwestern Wise County under SEVERE THUNDERSTORM WARNING until 4:30 pm.
3:34pm
Dual Pol shows the hail spike from the severe cell over Bowie. Pea sized hail reported moments ago.
3:32pm
Amateur Radio reports 1.75 inch hail in Jacksboro.
3:28pm
Several reports of golf-ball size hail with this cell entering the SW corner of Montague County.
3:24pm
T-Storm Warning for Montague County until 4 pm. Hail core heading right toward Bowie.
3:19pm
Reports of one inch hail in North Jacksboro from 3:09 pm.
3:13pm
T-Storm Warning NE Jack County and NW Wise County until 3:45pm. 60mph winds and golf ball sized hail possible.
We are under a SEVERE THUNDERSTORM Watch until 11pm.?
A line of storms is already producing T?Storm Warnings this afternoon over Young, Jack and Stephens Counties. Quarter size hail and 60 mph winds are the main threat.
The line should hang over our Northwest counties for the balance of the day. By evening we?ll have some better upper air support move into north Texas. The ?sweet spot? is just ahead of the area shaded in red just E, NE of the bottom of the trough.
FutureSky Forecast puts the line into the metro area by later tonight. Here is how the computer model looks at 11pm:
We?ll be in the weather center through the night watching this line. Join us at 6pm on CBS11 for a live report. Follow me on @cbs11jeffrey for the up-to-the-minute Tweets on the severe weather.
Source: http://dfw.cbslocal.com/2013/03/09/severe-weather-outbreak-todaytonight/
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'Nightmare bacteria,' strains of superbugs resistant to even the most powerful antibiotics, have quadrupled in number in the last decade?and have been found lurking in hospitals in 42 states. NIH epidemiologist Tara Palmore and infectious disease specialist Brad Spellberg discuss how to find and contain these bugs, and a few ways we might outsmart them.
Source: http://www.npr.org/2013/03/08/173821490/nightmare-bacteria-defy-even-last-ditch-drugs?ft=1&f=1007
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The Sony Electronic Viewfinder for Cyber-shot RX1 ($449.99 direct) is an add-on viewfinder for Sony's full-frame compact camera, the Cyber-shot DSC-RX1. It slides into the camera's multi-accessory hot shoe and gives you an eye-level look at what would typically be fed to the RX1's rear LCD.
The finder is identical in size and design to the similar FDAEV1S Electronic Viewfinder for select Sony NEX cameras. It shares the same 2.4-megapixel OLED design with that finder as well as the EVFs that are built into Sony's top-end interchangeable lens cameras like the Alpha 99 and NEX-6. The EVF is hinged, so it can tilt straight up to 90 degrees, but it isn't possible to lock it at any position.
Photographers who prefer to put their eyes up to the camera, and those who expect to use the RX1 on the brightest of days, will appreciate the clarity the EVF provides. It's smaller and comprises more pixels than the camera's rear LCD. This results in an image that is fantastically clear, which is especially helpful when focusing manually. You can set the camera to manually switch between the LCD and EVF via the Finder/LCD button on the left side of the eyepiece, or set the change occur automatically via an eye-sensor. Sony includes two eyepieces?one with a larger flexible rubber eyecup and one with a smaller ridged plastic eyecup.
The Electronic Viewfinder is one of two external finder options that Sony offers for the RX1. The other, a fixed optical finder, doesn't show you what your focus or depth of field will be?it simply provides approximate framing. The optical finder is priced even higher, at $600, but you can get away with using any shoe-mount optical finder that matches the field of view of a 35mm lens. Many of these are available used for very little money, as they were a popular accessory with vintage rangefinder cameras.
The OLED EVF is a more modern take on this concept, offering completely accurate framing, real-time preview of your depth of field and exposure, and the automatic magnification as a focus aid when manual focus is enabled. It's expensive, but so is the RX1?if you're going to spend $2,800 on the camera, you should budget the extra $450 for the EVF as it greatly enhances the shooting experience. Being able to bring up the camera to your eye is a welcome feeling for experienced photographers, and if you're shooting on a bright day it will eliminate the glare that sometimes makes using a rear LCD a difficult proposition. It would be nice if you were able to lock it in the 0, 45-, and 90-degree positions, and it would be nice if it was less expensive; but you can't argue with the clarity that the high-resolution OLED display provides.
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Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/7NaH4cf0jIo/0,2817,2416356,00.asp
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Mar. 7, 2013 ? What happens when human brain cells that surround and support neurons are implanted into the brains of newborn mice? Researchers reporting in the March 7th issue of the Cell Press journal Cell Stem Cell recently found that such mice had enhanced learning and memory when compared with normal mice that hadn't received the transplanted human cells. The findings indicate that these supportive cells, called glia, play an important role in human cognition.
As the human brain evolved, glia became much larger and more varied than those in the brains of rodents. Glia do not conduct electrical impulses like neurons do, but they can modulate neural activity, leading researchers to wonder how these evolutionary changes have benefited humans.
"To assess the species-specific contribution of glia to neural processing and plasticity and the specific advantages, if any, of human glia in cognition, we grafted human glial progenitor cells into the brains of newborn mice and then waited for the mice to grow to adulthood," explains Dr. Steve Goldman, who together with his collaborator Dr. Maiken Nedergaard directs the Center for Translational Neuromedicine at the University of Rochester Medical Center. "We then assessed both neurophysiological and behavioral measures of learning and memory, finding that the engrafted mice exhibited more rapid learning of both conditioned associations and goal-directed tasks." The neuronal connections within their brains also demonstrated characteristics of enhanced learning.
These findings indicate that human glia differ functionally from those of rodents and that they contribute significantly to learning. "As such, our findings suggest that the evolution of human cognition may reflect the development of human-specific glial form and function," says Dr. Goldman.
In a parallel study published in the journal in early February, Dr. Goldman and his team reported that they could efficiently generate glial progenitor cells from human skin cells reprogrammed into induced pluripotent cells. As a result, the researchers can now establish glial progenitor cells on a patient-specific basis from individuals with brain diseases, including a number of neuropsychiatric and neurological disorders that are relatively specific to humans. By implanting these cells into mice as they did in this most recent study, the investigators can assess the role of glial cells in these disorders, as well as test different treatment strategies that target abnormal glial function. They are currently carrying out these experiments with cells from patients with schizophrenia and Huntington's disease.
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/RPYW4xrU0zE/130307123947.htm
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Now the bad news: That will no longer be true 87 years from now, according to scientists who have conducted a comprehensive analysis of the planet's climate history since the world's ice sheets began their most recent retreat from North America and Europe.
New research into Earth's ancient climate is providing a clearer, more detailed view of how the planet's average surface temperature fluctuated over the period known as the Holocene epoch, which continues today. It's the time in which humans truly began making their mark on the planet, abandoning their hunting and gathering traditions and adopting a settled, agricultural lifestyle.
In a study published in Friday's edition of the journal Science, researchers used eight indirect temperature indicators ? such as pollen and shells from marine organisms ? to chart long-term global warming and cooling trends. The research team concluded that temperatures in the last decade had not exceeded the Holocene's steamiest periods from thousands of years ago. However, if current warming trends hold, those records will be broken by the end of the century.
?By the year 2100, we will be beyond anything human society has ever experienced,? said study leader Shaun Marcott, a postdoctoral researcher at Oregon State University's College of Earth, Ocean and Atmospheric Sciences.
According to NASA, the average global temperature for 2012 was 58.3 degrees Fahrenheit, making it the ninth-hottest year in recorded history. However, there is no single, agreed-upon method of calculating these temperatures, so scientists tend to discuss climate change by highlighting deviations from a specific reference point.
While a 1-degree Fahrenheit increase sounds small, it represents an enormous amount of heat energy. For instance, a 10-degree drop would plunge the world into another period of major glaciation, while every 1.8-degree increase would gradually amount to a roughly 65-foot rise in sea level due to melting polar ice, according to NASA climatologist James Hansen.
Previous efforts to measure past climate conditions have relied heavily on measurements of tree ring thickness. At high latitudes, tree growth is controlled mostly by temperature, so thick rings suggest warm years. But trees don't live longer than several thousand years, so those efforts have focused on shorter periods of time ? just 1,500 to 2,000 years.
These earlier studies have also featured ?hockey stick? graphs, in which average temperatures fluctuate in a long band that vaguely resembles the shaft of a hockey stick before rising sharply in the last 100 years, like the hockey stick's blade. Such diagrams have generated virulent criticism from those who rebut the idea that man-made greenhouse gases are heating the climate.
Marcott and colleagues from Harvard University said that by estimating temperature fluctuations for the entire Holocene, they hoped to provide a new perspective on the debate.
The researchers collected data from 73 sites across the globe, on land and beneath the sea. They included ice cores from Greenland, stalagmites in Borneo, and fossilized pollen in Scandinavia.
Some of the data came from the shells of long-dead aquatic microbes that were buried as many as 50 feet or more below the ocean floor. The shells' chemical makeup gives scientists clues about the water temperature at the time the creatures existed ? shells formed in warm water will have a greater percentage of stable oxygen isotopes, while shells formed in cold water will have a lower ratio.
Similarly, sediment core samples taken from the bottom of a pond, lake or ocean will contain fossilized pollen grains, which have very distinctive shapes when viewed under a microscope. By examining the variety of species and their abundance, scientists can gauge the area's past climate.
Trans fats produced by a type of algae were also used in the study as temperature indicators. The chemical bonds of these fat molecules, called alkenones, change according to water temperature. When the algae die, the alkenones sink to the bottom of the sea or lake bed, where they are mostly preserved.
What the researchers found was a climate that warmed and cooled gradually over a period of milleniums, then experienced a sudden, unprecedented rise in temperatures ? similar to earlier hockey stick graphs.
After the retreat of vast ice sheets in the Northern Hemisphere, global average temperature rose roughly 1 degree from the start of the Holocene to about 9,500 years ago, authors found. Average temperatures then plateaued for roughly 4,000 years, with the exception of two relatively short-lived spikes.
After that, things began to cool again. From about 5,500 years ago to roughly a century ago, average global surface temperature dropped 1.3 degrees.
But what concerns many scientists is what occurred next: In just the last 100 years, the average temperature has increased by 1.3 degrees. Although global temperatures of the last decade have not exceeded peak Holocene highs, they are warmer than 75% of the epoch.
?Global temperature, therefore, has risen from near the coldest to the warmest levels of the Holocene within the past century,? the researchers wrote.
By the end of the century, climate warming models predict an additional increase of 2 to 11.5 degrees, due largely to carbon emissions, the study noted.
The Science study was not the first to use such proxies to assess the ancient climate, but it was the first to pull together so many of them from all over the world, the researchers said. Previous studies used only regional data, which may be influenced by localized events like monsoons and the cyclical ocean-warming phenomenon known as El Ni?o.
Michael Mann, a physicist and climatologist at Pennsylvania State University who was not involved in the study, said the paper was important because it illustrated clearly that the rate and magnitude of recent warming was unprecedented in at least the last 11,000 years.
?We know that there were periods in the past that were warmer than today ? for example, the Cretaceous period 100 million years ago,? he said. ?The real issue is the rate of change, because that's what challenges our adaptive capacity.?
Mann, who was among the first climate scientists to introduce the hockey stick graph a decade ago ? and has been strongly criticized by climate warming skeptics ever since ? said the authors should prepare themselves for similar judgment.
?I am certain that professional climate-change deniers will attack the study and the authors, in an effort to discredit this important work,? Mann said.
monte.morin@latimes.com
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Source: http://www.sciencedaily.com/rss/mind_brain/child_development.xml
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